Alpha-epoxyabiraterone acetate, CAS 2484719-11-9은 아비라테론 유래의 산소화 공정 불순물로, 스테로이드 측쇄의 alpha 올레핀 위치에서 에폭시화가 일어나고 아세테이트 에스터 기능은 유지된다. 분자식 C26H33NO3, 분자량 407.5의 이 화합물은 단순 분해산물이 아니라 구조적으로 변형된 산화 유도체이다. 생성은 합성 또는 저장 중의 산화 스트레스, 특히 과산 또는 반응성 산소종 노출과 관련된다. 미량 정량에는 일반적으로 LC-MS/MS 또는 고분해능 LC-MS가 필요하며, NMR에 의한 정합 확인과 필요 시 안정성 지표적 조건에서의 LC-UV 불순물 프로파일링이 병행된다.
References
Kavitapu, DasameswaraRao, et al. “New Stability Indicating RP-HPLC Method for the Determination of Abiraterone Acetate, Its Related Substances and Degradation Products in Bulk and Dosage Form.†Materials Today: Proceedings, vol. 34, 2021, pp. 469–78, https://doi.org/10.1016/j.matpr.2020.02.665. ?Mach, Samuel, et al. “Epoxidation Is the Preferred Pathway of First-Stage Metabolism of Abiraterone Acetate in Brown Bullhead (Ameiurus Nebulosus).†Environmental Science and Pollution Research, vol. 26
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