alpha Lipoic Acid Impurity F, CAS 2114407-76-8은 alpha-리포산 골격과 연관된 황 함유 공정 관련 불순물로 정의된다. 분자식 C8H14O3S2, 분자량 222.32 g/mol이며, 모체 항산화 구조가 아니라 디티올란 고리의 산화적 변형체에 해당한다. 이러한 불순물은 합성 중, 황 교환 반응, 또는 이황화 고리의 통제된 산화 과정에서 생성될 수 있다. 확인 및 정량에는 일반적으로 LC-MS/MS, 고분해능 질량분석, 직교 HPLC가 요구되며, 구조 확인에는 NMR이 사용된다. 그 평가는 최신 규제 과학에서의 불순물 프로파일링과 규격 설정 원칙에 따라 이루어진다.
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