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포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

2484719-26-6Beta-Epoxyabiraterone Acetate

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카탈로그 번호:	VE006954
CAS 번호:	2484719-26-6
분자식:	C26H33NO3
분자량:	407.5 g/mol

견적 요청

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에 대한 추가 정보 CAS 2484719-26-6

모약물

Abiraterone

IUPAC명

17-(Pyridin-3-yl)-16β,17β-epoxyandrost-5-en-3β-yl acetate

약전 동의어

N/A

Other Synonyms

[(1R,2S,4S,6S,7S,10S,11R,14S)-7,11-dimethyl-6-pyridin-3-yl-5-oxapentacyclo[8.8.0.02,7.04,6.011,16]octadec-16-en-14-yl] acetate

Smile

CC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)C[C@@H]5[C@]4(O5)C6=CN=CC=C6)C)C

InChI

InChI=1S/C26H33NO3/c1-16(28)29-19-8-10-24(2)17(13-19)6-7-20-21(24)9-11-25(3)22(20)14-23-26(25,30-23)18-5-4-12-27-15-18/h4-6,12,15,19-23H,7-11,13-14H2,1-3H3/t19-,20+,21-,22-,23+,24-,25-,26+/m0/s1

설명

Beta-epoxyabiraterone acetate , also known as [(1R,2S,4S,6S,7S,10S,11R,14S)-7,11-dimethyl-6-pyridin-3-yl-5-oxapentacyclo[8.8.0.02,7.04,6.011,16]octadec-16-en-14-yl] acetate is a highly characterized reference material. It fully complies with stringent regulatory standards, including those set by USP, EMA, JP, and BP. This product is essential for use in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Abiraterone. Moreover, it comes with a detailed Structure Elucidation Report (SER), ensuring its accuracy and reliability for a wide range of analytical applications. It is a metabolite of Abiraterone acetate that is a derivative of steroidal progesterone and is used in the treatment of metastatic castration (mCRPC) and treatment of metastatic high-risk castration-sensitive prostate cancer.

References

Kavitapu, DasameswaraRao, et al. â€œNew Stability Indicating RP-HPLC Method for the Determination of Abiraterone Acetate, Its Related Substances and Degradation Products in Bulk and Dosage Form.â€ Materials Today: Proceedings, vol. 34, 2021, pp. 469â€“78, https://doi.org/10.1016/j.matpr.2020.02.665. ?Mach, Samuel, et al. â€œEpoxidation Is the Preferred Pathway of First-Stage Metabolism of Abiraterone Acetate in Brown Bullhead (Ameiurus Nebulosus).â€ Environmental Science and Pollution Research, vol. 26