D-Glu(4)-Teriparatide는 테리파라타이드의 펩타이드 불순물로서, 천연 Asn4 잔기가 D-글루탐산으로 치환된 산화적 탈아미드화 유래 서열 변이체이다. 이로 인해 전하 분포와 입체구조 거동이 달라진 디아스테레오머 성격의 종이 형성된다. 이러한 종은 펩타이드 합성 중의 부반응, 라세미화, 또는 Asn 탈아미드화와 에피머화 경로를 포함한 스트레스성 분해 과정에서 생성될 수 있다. 분자식과 분자량이 부여되지 않았으므로, 특성 규명은 intact-mass LC-MS, LC-MS/MS 기반 펩타이드 매핑, 그리고 RP-HPLC 또는 모세관 전기영동과 같은 직교 분리에 의존한다. 평가는 펩타이드 의약품의 불순물 관리 원칙에 따라 수행된다.
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