Escitalopram Desfluoro Impurity (HBr salt), CAS 1346617-30-8은 SSRI인 에스시탈로프람의 할로겐 결손 구조 유사체로, 분자식 C20H23BrN2O 및 분자량 387.31을 갖는다. HBr 염은 염기성 아민의 양성자화 형태를 의미하며, desfluoro 특성은 합성 중 또는 후속 변환 단계에서 방향족 플루오린 치환기가 소실되었음을 나타낸다. 이러한 불순물은 불완전한 플루오린화, 방향족 치환 오류, 또는 할로겐 교환에 의해 생성되는 공정 유래 부산물로 분류된다. 규제 평가는 ICH Q3A/Q3B 원칙에 따르며, 미량 검출 및 정량에는 LC-MS/MS, LC-HRMS, 정규성 상보적 크로마토그래피가 필요하고, 구조 확인에는 NMR이 사용된다.
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