재고 위치

New Jersey, USA
Czech Republic, EU
Mumbai, India

* 재고 가용성에 따라 다름

Documentation

MSDS 다운로드

샘플 COA 다운로드

포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

N-Nitroso 2-acetyl-2-decarbamoyldoxycycline

● Under Development

카탈로그 번호:	VE0018720
CAS 번호:	N/A
분자식:	C22H22N2O9
분자량:	458.4 g/mol

무엇을 도와드

RFQ 목록에 추가

에 대한 추가 정보

모약물

Doxycycline

IUPAC명

N-((1S,4aS,11R,11aR,12S,12aR)-3-acetyl-2,4a,5,7,12-pentahydroxy-11-methyl-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracen-1-yl)-N-methylnitrous amide

Pharmacopeial Synonyms

N/A

동의어

N/A

SMILES

O=NN([C@@H]([C@@]1([H])[C@]2(O)C(O)=C3[C@]([C@@H](C)C4=CC=CC(O)=C4C3=O)([H])[C@@H]1O)C(O)=C(C(C)=O)C2=O)C

InChI

InChI=1S/C22H22N2O9/c1-7-9-5-4-6-10(26)13(9)17(27)14-11(7)18(28)15-16(24(3)23-33)19(29)12(8(2)25)20(30)22(15,32)21(14)31/h4-7,11,15-16,18,26,28-29,31-32H,1-3H3/t7-,11+,15+,16-,18-,22+/m0/s1

설명

N-Nitroso 2-acetyl-2-decarbamoyldoxycycline is the N-nitroso derivative and a nitrosamine impurity arising from nitrosation of 2-acetyl-2-decarbamoyldoxycycline during synthesis or storage. As a nitrosamine-class impurity it is associated with potential genotoxicity and therefore requires stringent control and sensitive quantification. Analytical characterization typically employs LC-MS/MS or GC-MS with tailored sample preparation such as solid phase extraction and method validation to achieve ng per gram detection limits. Control strategies include monitoring nitrite levels, adjusting synthesis pH, and implementing in-process controls. Accurate identification, impurity profiling and regulatory-compliant limits are critical for risk assessment and release testing.