N-니트로소피페라진 모노머, 즉 모노니트로소피페라진은 분자식 C4H9N3O, 분자량 115.13 g/mol 을 갖는 고리형 니트로소아민 불순물이다. CAS 5632-47-3 은 피페라진의 N-니트로소 유도체를 지칭하며, 이 계열은 대사적 활성화, DNA 알킬화, 그리고 ICH M7 관점의 유전독성 우려와 연관된다. 생성은 합성 중 니트로소화 조건에서의 부반응 또는 피페라진 함유 중간체의 오염으로 발생할 수 있다. 구조 확인과 초미량 정량에는 일반적으로 LC-MS/MS 또는 GC-MS 가 요구되며, 휘발성 니트로소아민에 맞춘 크로마토그래피 분리와 인공적 니트로소화의 엄격한 통제가 필요하다.
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