N-Nitroso Desethyl Abemaciclib는 abemaciclib 골격과 연관된 니트로사민 불순물로, 합성 또는 보관 중 desethyl 아민 전구체에 니트로소화 조건이 작용하면서 생성될 가능성이 있다. 분자식은 C25H27F2N9O, 분자량은 507.54 g/mol이며, N-니트로소 모티프를 포함하므로 독성학적 검토가 중요하다. 관련 니트로사민은 ICH M7 원칙에 따라 잠재적 유전독성 불순물로 관리되는 경우가 많다. 극미량 특성화와 정량에는 일반적으로 LC-MS/MS가 요구되며, 정확 질량 확인을 위한 LC-HRMS가 자주 병행된다. 휘발성이 허용되면 GC-MS도 사용된다. 구조 판정 시에는 호변이성 및 이온화 거동이 크로마토그래피 유지와 MS 응답에 미치는 영향을 고려해야 한다.
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