N-Nitroso Desethyl Abemaciclib ist eine Nitrosamin-Impurität des Abemaciclib-Gerüsts, die plausibel durch nitrosierende Bedingungen auf den Desethyl-Aminvorläufer während Synthese oder Lagerung entsteht. Mit der Summenformel C25H27F2N9O und einer Molmasse von 507,54 g/mol trägt sie das N-Nitroso-Motiv, das aus toxikologischer Sicht relevant ist, da verwandte Nitrosamine nach den Grundsätzen von ICH M7 häufig als potenziell genotoxische Verunreinigungen eingestuft werden. Die Spurenanalytik erfordert in der Regel LC-MS/MS mit hochauflösender Massenspektrometrie, häufig ergänzt durch LC-HRMS und, sofern die Flüchtigkeit geeignet ist, GC-MS. Bei der Strukturzuordnung sind Tautomerie und Ionisationsverhalten zu berücksichtigen.
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