N-Nitroso Upadacitinib (Possibility 1)는 upadacitinib에서 유래할 수 있는 니트로사민 계열 공정 불순물로, 합성, 보관 또는 시약 잔류 과정에서 생성된 니트로사화 종에 의해 피페리딘 질소 또는 아마이드 관련 질소가 니트로사화되면서 형성될 가능성이 있다. 분자식 C17H18F3N7O2, 분자량 409.4 g/mol이며, N-니트로소 기능기는 일반적으로 유전독성 우려와 연관되므로 ICH M7 원칙에서 평가되는 잠재적 변이원성 불순물 범주에 속한다. 구조 확인과 극미량 정량에는 LC-MS/MS, 고해상도 MS가 통상 필요하며, 휘발성이 허용될 경우 GC-MS도 적용되고, 선택반응 모니터링과 동위원소 희석법이 자주 사용된다.
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