N-니트로소노르플록사신(CAS 74011-53-3)은 노르플록사신의 N-니트로소아민 유도체로, 산성 또는 산화적 제조 조건에서 2차 아민 기능기의 니트로소화에 의해 생성될 수 있는 잠재적 유전독성 불순물로 분류된다. 분자식은 C16H17FN4O4이며 분자량은 348.33 g/mol이다. 규제 관점에서 이 계열은 DNA 반응 가능성 때문에 ICH M7에 따라 엄격하게 평가된다. 극미량 정량에는 일반적으로 높은 선택성의 LC-MS/MS가 요구되며, 고분해능 질량분석이 자주 병행된다. 경우에 따라 유도체화 또는 농축 후 GC-MS가 적용될 수 있고, 구조 확인은 조각 이온 해석과 동위원소 패턴 분석에 기반한다.
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