(R)-3-아미노피페리딘 이염산염, CAS 334618-23-4는 3-위치에 1차 아민을 갖는 키랄 포화 헤테로고리의 염산염이다. 분자식 C5H14Cl2N2, 분자량 173.08 g/mol이며, 피페리딘 화학에서는 입체선택적 분리의 불완전성이나 환원적 아민화 및 고리 형성 단계의 부반응으로부터 유래하는 공정 관련 불순물 또는 합성 중간체로 관찰될 수 있다. 염기성이고 극성인 아민이므로, 평가는 일반적으로 LC-MS/MS, HILIC-LC, 키랄 분리를 필요로 하며, 휘발성 유도체 분석이 필요한 경우 유도체화 후 GC-MS가 사용된다. 규제 관점에서는 불순물의 기원과 엔안티오머 순도가 핵심이다.
References
Petri, Antonella, et al. “Asymmetric Synthesis of a High Added Value Chiral Amine Using Immobilized o-Transaminases.” Beilstein Journal of Organic Chemistry, vol. 15, Jan. 2019, pp. 60–66, https://doi.org/10.3762/bjoc.15.6.
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