Phloroglucinol is an organic compound with the formula C₆H₃(OH)₃. It is a colorless solid. It is used in the synthesis of pharmaceuticals and explosives. Phloroglucinol is one of three isomeric benzenetriols. The other two isomers are hydroxyquinol and py + some more technical info. The compound has a molecular weight of 126.11 g mol-1 and the IUPAC name 1,3,5-trihydroxybenzene. It forms a crystalline material with good thermal stability and shows moderate solubility in water and higher solubility in polar organic solvents such as ethanol and acetone. In synthetic chemistry it functions as a tri-phenolic scaffold that undergoes electrophilic substitution, acylation, alkylation and oxidative coupling reactions. Quality control and structural confirmation are routinely performed by HPLC, NMR, IR and melting point analysis.
Parent: Phloroglucinol Dihydrate / Phloroglucinol
Parent: Phloroglucinol
Parent: Phloroglucinol
Parent: Phloroglucinol
Parent: Phloroglucinol
Parent: Phloroglucinol
Parent: Phloroglucinol
Parent: Phloroglucinol
Typical pharmaceutical and high purity technical specifications list assay values commonly in the 98.0 to 100.0% range with total organic impurities generally controlled below 1.0% by HPLC. Individual related compounds such as pyrogallol and hydroxyquinol are typically limited to under 0.5% each with combined related substances kept below 1.0%. Water content is commonly specified below 0.5% by Karl Fischer titration. Heavy metals are usually restricted to 10 ppm or lower and residual solvents are controlled to relevant ICH limits. Higher molecular weight oxidative degradation products and polymeric tars are monitored during stability testing and are expected to be trace to not detected in pharmaceutical grade material.
Phloroglucinol is used as an antispasmodic agent in some countries to relieve smooth muscle spasms in the gastrointestinal tract, biliary tract and other visceral spasms; approved indications and availability vary by jurisdiction and it is typically a prescription medication.
The IUPAC name is 1,3,5-trihydroxybenzene.
Phloroglucinol may be prescribed in combination with analgesics for dysmenorrhea in certain clinical settings, but practices vary and treatment should follow local clinical guidance and a prescribers recommendation.
Phloroglucinol serves as a versatile synthetic building block in pharmaceutical and fine chemical synthesis, acts as an antispasmodic in clinical use, and is employed as a reagent in analytical chemistry and specialty industrial applications.
