Aclidinium Impurities

Aclidinium belongs to the bronchodilator class of medicines.

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Parent Drug Name Name of Impurity Catalogue No.
Aclidinium Aclidinium Bromide Impurity 1 VL5310002View
Aclidinium Aclidinium Bromide Impurity 2 VL5310003View

Aclidinium Related Compound

It acts mainly by reducing stiffness and widening the lungs’ air channels, making breathing easier. It is used as a long-term treatment to prevent breathing problems such as shortness of breathing, coughing, and discomfort in the chest in patients with chronic obstructive pulmonary disease (COPD, a group of diseases affecting the lungs and airways), such as chronic bronchitis (swelling of the airways leading to the lungs) and emphysema (damage to air sacs in the lungs).

References

FAQ

Is aclidinium a bronchodilator?

Aclidinium is the Worldwide Initiative for Chronic Obstructive Lung Disease advocates treating COPD on a regular schedule with long-acting bronchodilators such as anticholinergics, which are safer and easier to use than short-term bronchodilators.

Is aclidinium an anticholinergic drug?

Aclidinium is a synthetic anticholinergic drug used to treat acute bronchospasm caused by persistent bronchitis or emphysema as an inhalant. Acetylcholine has been shown to reduce bronchial smooth muscle spasms and alleviate bronchospasm in individuals with chronic obstructive pulmonary disease (COPD).

What is the mechanism of action of aclidinium?

Aclidinium is a prolonged-acting muscarinic receptor inhibitor with equal affinity to subtypes M1 through M5. M3 receptors are found on bronchial smooth muscle, vascular endothelium in the lung, and submucosal mucus glands, where they influence bronchoconstriction, production of mucus, and vasodilation. Aclidinium bromide exerts its pharmacological actions by inhibiting the M3 receptor in smooth muscle, resulting in bronchodilation.

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Aclidinium Bromide Impurity 1

Aclidinium Bromide Impurity 1
Catalogue No.

VL5310002

CAS No.

N/A

Molecular Formula

C20H25BrNO3S2. Br

Molecular Weight

551.36 g/mol

Parent drug

Aclidinium

IUPAC Name

(R)-1-(3-bromopropyl)-3-(2-hydroxy-2, 2-di(thiophen-2-yl)acetoxy)quinuclidin-1-ium bromide

Synonyms

N/A

References

Sci-Hub, Effect of Aclidinium Bromide on Major Cardiovascular Events and Exacerbations in High-Risk Patients With Chronic Obstructive Pulmonary Disease. JAMA, 321(17), 1693, 10.1001/jama.2019.4973. (2019). Retrieved June 13, 2022, from Sci-hub.se website: https://sci-hub.se/10.1001/jama.2019.4973

Status

In-stock

ListName

Aclidinium Bromide Impurity 1

Exclusively Supplied by Veeprho

Exclusively Supplied by Veeprho

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