| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Aclidinium | Aclidinium Bromide Impurity 1 | VL5310002 | View |
| Aclidinium | Aclidinium Bromide Impurity 2 | VL5310003 | View |
Aclidinium Related Compound
It acts mainly by reducing stiffness and widening the lungs’ air channels, making breathing easier. It is used as a long-term treatment to prevent breathing problems such as shortness of breathing, coughing, and discomfort in the chest in patients with chronic obstructive pulmonary disease (COPD, a group of diseases affecting the lungs and airways), such as chronic bronchitis (swelling of the airways leading to the lungs) and emphysema (damage to air sacs in the lungs).
References
- Chanez, Pascal, et al. Aclidinium Bromide Provides Long-Acting Bronchodilation in Patients with COPD. no. 1, Feb. 2010, pp. 15–21, https://doi.org/10.1016/j.pupt.2009.08.001. Accessed 13 June 2023.
- “Aclidinium.” Nih.gov, National Institute of Diabetes and Digestive and Kidney Diseases, 7 July 2017, www.ncbi.nlm.nih.gov/books/NBK548832/#:~:text=Aclidinium%20is%20a%20synthetic%20anticholinergic,to%20chronic%20bronchitis%20or%20emphysema. Accessed 13 June 2023.
- Pisano, Michele, and Nissa Mazzola. “Aclidinium Bromide Inhalation Powder (Tudorza): A Long-Acting Anticholinergic for the Management of Chronic Obstructive Pulmonary Disease.” P & T : A Peer-Reviewed Journal for Formulary Management, vol. 38, no. 7, 2013, pp. 393–96, www.ncbi.nlm.nih.gov/pmc/articles/PMC3776488/#:~:text=Mechanism%20of%20Action&text=Aclidinium%20bromide%20exhibits%20its%20pharmacological,smooth%20muscle%2C%20resulting%20in%20bronchodilation. Accessed 13 June 2023.
FAQ
Is aclidinium a bronchodilator?
Aclidinium is the Worldwide Initiative for Chronic Obstructive Lung Disease advocates treating COPD on a regular schedule with long-acting bronchodilators such as anticholinergics, which are safer and easier to use than short-term bronchodilators.
Is aclidinium an anticholinergic drug?
Aclidinium is a synthetic anticholinergic drug used to treat acute bronchospasm caused by persistent bronchitis or emphysema as an inhalant. Acetylcholine has been shown to reduce bronchial smooth muscle spasms and alleviate bronchospasm in individuals with chronic obstructive pulmonary disease (COPD).
What is the mechanism of action of aclidinium?
Aclidinium is a prolonged-acting muscarinic receptor inhibitor with equal affinity to subtypes M1 through M5. M3 receptors are found on bronchial smooth muscle, vascular endothelium in the lung, and submucosal mucus glands, where they influence bronchoconstriction, production of mucus, and vasodilation. Aclidinium bromide exerts its pharmacological actions by inhibiting the M3 receptor in smooth muscle, resulting in bronchodilation.
