Antazoline Impurities

Antazoline is an antihistamine that is used to treat nasal congestion and allergic conjunctivitis.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Antazoline EP Impurity A Antazoline

Antazoline EP Impurity A

VL6670002 26953-37-7

Antazoline Related Compound

It is a first-generation antihistamine that also has anticholinergic properties. It’s used to treat nasal is a mast-cell stabilizer, such as sodium cromoglicate or nedocromil, and can be taken orally or topically to alleviate itching, erythema, tearing, and swelling caused by allergen exposure.


  • Waller, Derek G., and Anthony P. Sampson. Antihistamines and Allergic Disease. Jan. 2018, pp. 451–56, Accessed 20 July 2023.
  • Miller J;Wolf EH. “Antazoline Phosphate and Naphazoline Hydrochloride, Singly and in Combination for the Treatment of Allergic Conjunctivitis-a Controlled, Double-Blind Clinical Trial.” Annals of Allergy, vol. 35, no. 2, Ann Allergy, 2013, Accessed 20 July 2023.


Antazoline belongs to what drug class?

Antazoline is an imidazoline that is 2-aminomethyl-2-imidazoline with benzyl and phenyl groups replacing the exocyclic amino hydrogens. Antazoline is only discovered in those who have used the substance. It functions as an H1-receptor antagonist, cholinergic antagonist, and xenobiotic.

What are Antazoline hydrochloride eye drops?

Antazoline is an antihistamine that is derived from ethylenediamine and is used to treat rhinitis and conjunctivitis. It is used in nose drops and eye drops as a hydrochloride, phosphate, or sulfate, most typically in a concentration of 0.5%; mesylate has also been employed.

What is the use of Antazoline?

Nasal drops and nasal sprays containing antazoline are used to treat nasal congestion caused by hay fever and other types of allergic rhinitis.