Atomoxetine Impurities

Atomoxetine is approved for the treatment of attention deficit hyperactivity disorder (ADHD) in adults and children over the age of six.

Show
per page
Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Atomoxetine EP Impurity A (Free Base) Atomoxetine

Atomoxetine EP Impurity A (Free Base)

VE007285 56161-70-7
Atomoxetine EP Impurity A (HCl Salt) Atomoxetine

Atomoxetine EP Impurity A (HCl Salt)

VE006841 873310-33-9
Atomoxetine EP Impurity B (Free Base) Atomoxetine

Atomoxetine EP Impurity B (Free Base)

VE0020509 105314-53-2
Atomoxetine EP Impurity B (HCl Salt) Atomoxetine

Atomoxetine EP Impurity B (HCl Salt)

VE0011252 82857-39-4
Atomoxetine EP Impurity C (Free Base) Atomoxetine

Atomoxetine EP Impurity C (Free Base)

VE007289 56161-78-5
Atomoxetine EP Impurity C (HCl) Atomoxetine

Atomoxetine EP Impurity C (HCl)

VE007288 873310-31-7
Atomoxetine EP Impurity D (Free Base) Atomoxetine

Atomoxetine EP Impurity D (Free Base)

VE0020508 1643684-02-9
Atomoxetine EP Impurity D (HCl) Atomoxetine

Atomoxetine EP Impurity D (HCl)

VE0012405 1643684-05-2
Atomoxetine EP Impurity E Atomoxetine

Atomoxetine EP Impurity E

VL266001 17199-29-0
Atomoxetine EP Impurity F Atomoxetine

Atomoxetine EP Impurity F

VE007290 1010818-92-4
Atomoxetine EP Impurity F Atomoxetine

Atomoxetine EP Impurity F

VE0014525 2727370-25-2
Atomoxetine EP Impurity G Atomoxetine

Atomoxetine EP Impurity G

VE007291 N/A
Atomoxetine EP Impurity G DiHCl Atomoxetine

Atomoxetine EP Impurity G DiHCl

VE0012398 N/A
Atomoxetine EP Impurity H (R-Isomer) Atomoxetine

Atomoxetine EP Impurity H (R-Isomer)

VE0012939 115290-81-8
Atomoxetine EP Impurity H (S-Isomer) Atomoxetine

Atomoxetine EP Impurity H (S-Isomer)

VE0012440 114133-37-8
Atomoxetine Impurity 1 HCl Atomoxetine

Atomoxetine Impurity 1 HCl

VL6360003 42064-62-0
Atomoxetine Impurity 14 HCl Atomoxetine

Atomoxetine Impurity 14 HCl

VE0012437 116939-14-1
Atomoxetine Impurity 16 Atomoxetine

Atomoxetine Impurity 16

VE0012439 95-48-7
Atomoxetine Impurity 2 Atomoxetine

Atomoxetine Impurity 2

VL266004 N/A
Atomoxetine Impurity 4 HCl Atomoxetine

Atomoxetine Impurity 4 HCl

VE0012406 N/A
Atomoxetine Impurity 5 Atomoxetine

Atomoxetine Impurity 5

VE0012420 2376668-89-0
Atomoxetine Impurity 6 (Mixture of Diastereomers) Atomoxetine

Atomoxetine Impurity 6 (Mixture of Diastereomers)

VE0012424 N/A
Atomoxetine Impurity 7 HCl Atomoxetine

Atomoxetine Impurity 7 HCl

VE0012427 N/A
Atomoxetine Impurity 8 HCl Atomoxetine

Atomoxetine Impurity 8 HCl

VE0012428 N/A
Atomoxetine N-Desmethyl Impurity Atomoxetine

Atomoxetine N-Desmethyl Impurity

VL266005 881995-46-6
Atomoxetine-D3 (HCl Salt) Atomoxetine

Atomoxetine-D3 (HCl Salt)

DVE00254 1217776-38-9
Desmethyl Atomoxetine Impurity Atomoxetine

Desmethyl Atomoxetine Impurity

VE0019878 1212823-01-2
N-Nitroso Atomoxetine Atomoxetine

N-Nitroso Atomoxetine

VE007664 N/A
4-Hydroxy Atomoxetine (S-Isomer) Oxalate Atomoxetine

4-Hydroxy Atomoxetine (S-Isomer) Oxalate

VE0012444 N/A
4-Hydroxy Atomoxetine Oxalate Atomoxetine

4-Hydroxy Atomoxetine Oxalate

VE0012433 457634-21-8
4?-Hydroxy Atomoxetine Glucuronide Atomoxetine

4?-Hydroxy Atomoxetine Glucuronide

VE0012454 540729-08-6
4'-Hydroxy Atomoxetine Atomoxetine

4'-Hydroxy Atomoxetine

VE0019776 435293-66-6
4'-Hydroxy Atomoxetine-D3 Hemioxalate Atomoxetine

4'-Hydroxy Atomoxetine-D3 Hemioxalate

DVE00253 N/A

Atomoxetine Related Compound

Although atomoxetine is only licensed by the FDA for the treatment of ADHD, it is occasionally used off-label to treat adult patients with treatment-resistant depression.

References

FAQ

What is the pharmacological action of atomoxetine?

The specific suppression of presynaptic NE reuptake in the PFC is likely to be linked to atomoxetine. Atomoxetine, a highly selective norepinephrine reuptake inhibitor (SNRI), binds to the NE reuptake transporter on the nerve’s presynaptic membrane and blocks NE reuptake.

Is atomoxetine used for depression?

Atomoxetine is a highly selective NET inhibitor, which is compatible with the anticipated method of action of antidepressants and antihypertensive medicines outlined below. Aside from its efficiency in the treatment of ADHD, atomoxetine is also effective in the treatment of co-occurring disorders such as anxiety, tics, and depression.

Does atomoxetine increase dopamine?

Because norepinephrine receptors are likewise sensitive to dopamine, atomoxetine is a selective norepinephrine reuptake inhibitor that promotes dopaminergic release in the frontal brain.