Avermectin Impurities

Avermectins are a class of medicines having numerous therapeutic targets.

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Parent Drug Name Name of Impurity Catalogue No.
Avermectin Avermectin B1a Impurity 1 VE0011734View
Avermectin / Abamectin Avermectin B1a Impurity 2 VE0011547View
Avermectin / Abamectin Avermectin B1a Impurity 3 VE0011548View
Avermectin / Abamectin Avermectin B1a Impurity 4 VE0011549View
Avermectin 12-Demethyl-12-ethyl Avermectin B1b VE0011601View

Avermectin Related Compound

Because of their anthelmintic and insecticidal characteristics, they are commonly employed as pesticides to treat pests and parasitic worms. The compounds are generated from a lactone ring with 16 members.

References

  • “Ivermectin: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2020, go.drugbank.com/drugs/DB00602. Accessed 30 July 2023.
  • Crump, Andy, and Satoshi Omura. Ivermectin, “Wonder Drug” from Japan: The Human Use Perspective. no. 2, Jan. 2011, pp. 13–28, https://doi.org/10.2183/pjab.87.13. Accessed 30 July 2023.
  • Gaber El-Saber Batiha, et al. Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects. no. 8, Aug. 2020, pp. 196–96, https://doi.org/10.3390/ph13080196. Accessed 30 July 2023.

FAQ

What drug class is avermectin?

Avermectin is a kind of drug known as an anthelmintic. It kills the worms in the intestines, therefore treating strongyloidosis. It kills the growing worms to cure onchocerciasis. Because ivermectin does not kill the adult worms that cause onchocerciasis, it will not cure the infection.

What is the mechanism of action of avermectin?

Action Mechanism. Avermectin prevents the propagation of electrical impulses in invertebrate muscles and neurons by increasing the glutamate effects on the invertebrate-specific gated chloride channel.

What is the therapeutic use of avermectin?

Head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis are all treated with this antiparasitic medicine.

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12-Demethyl-12-ethyl Avermectin B1b

12-Demethyl-12-ethyl Avermectin B1b
Catalogue No.

VE0011601

CAS No.

N/A

Molecular Formula

C48H72O14

Molecular Weight

873.09 g/mol

Parent drug

Avermectin

IUPAC Name

12-Demethyl-12-ethyl Avermectin B1b

Synonyms

N/A

Status

Under Development

ListName

12-Demethyl-12-ethyl Avermectin B1b

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