Avermectin Impurities

Avermectins are a class of medicines having numerous therapeutic targets.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Avermectin B1a Impurity 1 Avermectin

Avermectin B1a Impurity 1

VE0011734 N/A
Avermectin B1a Impurity 2 Avermectin / Abamectin

Avermectin B1a Impurity 2

VE0011547 N/A
Avermectin B1a Impurity 3 Avermectin / Abamectin

Avermectin B1a Impurity 3

VE0011548 N/A
Avermectin B1a Impurity 4 Avermectin / Abamectin

Avermectin B1a Impurity 4

VE0011549 N/A
12-Demethyl-12-ethyl Avermectin B1b Avermectin

12-Demethyl-12-ethyl Avermectin B1b

VE0011601 N/A

Avermectin Related Compound

Because of their anthelmintic and insecticidal characteristics, they are commonly employed as pesticides to treat pests and parasitic worms. The compounds are generated from a lactone ring with 16 members.

References

  • “Ivermectin: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2020, go.drugbank.com/drugs/DB00602. Accessed 30 July 2023.
  • Crump, Andy, and Satoshi Omura. Ivermectin, “Wonder Drug” from Japan: The Human Use Perspective. no. 2, Jan. 2011, pp. 13–28, https://doi.org/10.2183/pjab.87.13. Accessed 30 July 2023.
  • Gaber El-Saber Batiha, et al. Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects. no. 8, Aug. 2020, pp. 196–96, https://doi.org/10.3390/ph13080196. Accessed 30 July 2023.

FAQ

What drug class is avermectin?

Avermectin is a kind of drug known as an anthelmintic. It kills the worms in the intestines, therefore treating strongyloidosis. It kills the growing worms to cure onchocerciasis. Because ivermectin does not kill the adult worms that cause onchocerciasis, it will not cure the infection.

What is the mechanism of action of avermectin?

Action Mechanism. Avermectin prevents the propagation of electrical impulses in invertebrate muscles and neurons by increasing the glutamate effects on the invertebrate-specific gated chloride channel.

What is the therapeutic use of avermectin?

Head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis are all treated with this antiparasitic medicine.