Cinitapride Impurities

Cinitapride is used to treat gastrointestinal disorders such as:

• GERD (acid reflux)
• Functional dyspepsia
• Delayed gastric emptying (gastroparesis)
  It helps enhance gastric motility, reducing symptoms like bloating, nausea, early satiety, and heartburn.

Cinitapride has a multi-receptor mechanism:

• 5-HT₄ receptor agonist – stimulates gastrointestinal motility
• 5-HT₂ receptor antagonist – reduces gut spasms
• Dopamine D₂ antagonist – enhances acetylcholine release, promoting smooth muscle activity
  This combination improves coordination of digestive tract movements and prevents reflux.

• Cinitapride is generally safe when used under medical supervision for short to medium-term
• Long-term use is not typically recommended due to a lack of extensive safety data and the potential for tolerance or extrapyramidal side effects, though these are rare.
• It should be used cautiously in patients with neurological disorders or cardiac arrhythmias.

Common side effects include:

• Headache
• Drowsiness or dizziness
• Dry mouth
• Diarrhea or abdominal cramping
  Rare side effects:
• Extrapyramidal symptoms (involuntary movements, especially with prolonged use)
• Hormonal changes due to dopamine antagonism (very rare)