Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in Tabernanthe iboga and related species, including Tabernaemontana divaricata . It is an iboga-type monoterpene indole alkaloid characterized by an indole nucleus fused into the iboga skeleton with a carbomethoxy substituent at the C18 position and a basic tertiary nitrogen. The compound is typically encountered as a white to off-white crystalline material that is lipophilic and soluble in common organic solvents while forming salts in acidic media. Coronaridine is routinely characterized and quantified by reversed-phase HPLC with UV detection, high resolution mass spectrometry for accurate mass confirmation, and 1H and 13C NMR for structural verification. Typical lab handling notes include stability under refrigeration in inert atmosphere, susceptibility to oxidative degradation under prolonged exposure to air and light, and amenability to chromatographic purification and salt formation for analytical and research use.
For research and analytical grade material, typical acceptance criteria specify an assay by HPLC of greater than or equal to 98.0 percent area with total related impurities and unidentified peaks not exceeding 2.0 percent area. Common related alkaloids and degradation products detected in preparations or crude extracts, and their representative concentration ranges, are: ibogaine 0.1 to 1.0 percent w/w, voacangine 0.05 to 0.5 percent w/w, de-esterified or hydroxy-coronaridine analogs 0.05 to 1.0 percent w/w, and minor oxidized or dimeric impurities generally below 0.2 percent each. Individual specification limits used for quality control may restrict any single related compound to 0.5 percent or lower depending on intended use. Identification and quantitation of these related substances are performed by HPLC comparison to reference standards, MS fragmentation patterns, and NMR when needed.
Coronaridine is a naturally occurring monoterpene indole alkaloid isolated from plants such as Tabernanthe iboga and Tabernaemontana divaricata; it is defined chemically as 18-carbomethoxyibogamine and is used as a subject of chemical, pharmacological, and analytical research.
Coronaridine is an iboga-type monoterpene indole alkaloid with a basic tertiary amine, a carbomethoxy substituent at the 18 position, and properties typical of lipophilic indole alkaloids; it is characterized by techniques such as HPLC, MS, and NMR.
Yes, Coronaridine is a member of the iboga alkaloid family and shares the core iboga skeleton with other related alkaloids such as ibogaine and voacangine, differing by specific substituents at defined positions on the scaffold.
