Dexchlorpheniramine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body. Dexchlorpheniramine is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergic rhinitis and urticaria. Technically, dexchlorpheniramine is the dextrorotatory enantiomer of chlorpheniramine and acts primarily as an H1 receptor antagonist with measurable anticholinergic activity, which contributes to symptomatic relief of nasal and ocular secretions. The active pharmaceutical ingredient is typically supplied as the maleate salt to improve stability and aqueous solubility. Pharmacokinetic properties include oral absorption with onset within 30 to 60 minutes, distribution that includes central nervous system penetration which can cause sedation in some patients, hepatic metabolism via mixed function oxidases, and renal excretion of metabolites. Common formulation considerations include control of enantiomeric purity, residual solvent limits, and assurance of low levels of related synthetic intermediates to meet pharmacopeial quality standards.
Parent: Dexchlorpheniramine
Parent: Dexchlorpheniramine
Parent: Dexchlorpheniramine
Parent: Dexchlorpheniramine / Dexchlorpheniramine Maleate
Parent: Dexchlorpheniramine
Parent: Dexchlorpheniramine
Typical impurities and related compounds encountered during manufacture and quality control include the S enantiomer (the nonassigned enantiomer of chlorpheniramine), N-dealkylation products such as N-desmethyl derivatives, N-oxide oxidative products, epimerization or positional isomers from synthesis, residual solvents used in processing, and trace heavy metals from catalysts or equipment. Typical specification ranges used by manufacturers and reference monographs are individual related substances in the range of 0.05 to 0.5 percent weight by weight depending on qualification status, with total impurities commonly limited to 0.5 to 1.0 percent weight by weight; specific qualified impurities such as the N-desmethyl derivative are often limited to 0.1 to 0.2 percent. Enantiomeric purity is routinely monitored by chiral HPLC and is commonly specified to meet limits of 0.1 to 0.3 percent for the opposite enantiomer. Analytical controls include validated achiral HPLC with PDA or MS for related substances, chiral HPLC for enantiomeric excess, GC for residual solvents, and ICP-MS or AAS for elemental impurities.
Dexchlorpheniramine is used to relieve symptoms of allergic conditions such as allergic rhinitis and urticaria, including sneezing, runny nose, itchy and watery eyes, hives, and skin itching.
If by dexchloramine you mean dexchlorpheniramine, yes it commonly causes sedation in many users because it crosses the blood brain barrier; drowsiness is a known pharmacologic effect of first generation H1 antihistamines.
Chlorpheniramine is a racemic mixture containing two enantiomers while dexchlorpheniramine is the single dextrorotatory enantiomer; the dextrorotatory form is the pharmacologically active enantiomer and is typically more potent on a per milligram basis, so formulations and dosing may differ to reflect that increased activity.
Availability varies by jurisdiction; dexchlorpheniramine is sold over the counter in many countries in tablet and syrup formulations, but local regulations differ so check national or regional pharmacy guidance or consult a pharmacist.
