Mefenamic Impurities

Mefenamic acid is a pain reliever that is used to treat mild to moderate pain, especially menstrual pain (pain that occurs before or during a menstrual cycle).

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Mefenamic Acid EP Impurity A Mefenamic

Mefenamic Acid EP Impurity A

VL2950001 87-59-2
Mefenamic Acid EP Impurity B Mefenamic

Mefenamic Acid EP Impurity B

VE006497 21122-68-9
Mefenamic Acid EP Impurity C Mefenamic

Mefenamic Acid EP Impurity C

VL2950002. 118-91-2
Mefenamic Acid EP Impurity D Mefenamic

Mefenamic Acid EP Impurity D

VL2950003 65-85-0

Mefenamic Related Compound

Mefenamic acid belongs to the NSAID family of medicines. It works by inhibiting the formation of a chemical in the body that produces pain, heat, and inflammation.

References

  • “Mefenamic Acid.” Nih.gov, National Institute of Diabetes and Digestive and Kidney Diseases, 10 Jan. 2020, www.ncbi.nlm.nih.gov/books/NBK548029/#:~:text=Like%20other%20NSAIDs%2C%20mefenamic%20acid,largely%20for%20treatment%20of%20pain. Accessed 30 May 2023.
  • “Mefenamic Acid: MedlinePlus Drug Information.” Medlineplus.gov, 2021, medlineplus.gov/druginfo/meds/a681028.html#:~:text=Mefenamic%20acid%20is%20in%20a,pain%2C%20fever%2C%20and%20inflammation. Accessed 30 May 2023.
  • “Mefenamic Acid: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2014, go.drugbank.com/drugs/DB00784. Accessed 30 May 2023. ‌ ‌

FAQ

What is the mefenamic mechanism of action?

Mefenamic acid, like other NSAIDs, is a cyclo-oxygenase (Cox-1 and -2) inhibitor that inhibits the formation of intracellular prostaglandins that are involved in pain and inflammatory pathways. Mefenamic acid contains analgesic, antipyretic, and anti-inflammatory properties, however, it is mostly used to relieve pain.

Mefenamic acid belongs to what drug class?

Mefenamic acid belongs to the NSAID family of medicines. It works by inhibiting the formation of a chemical in the body that produces pain, heat, and inflammation.

What is the action of mefenamic acid?

Mefenamic acid binds to the prostaglandin synthetase receptors COX-1 and COX-2, decreasing prostaglandin synthetase activity. Because these receptors have a function in inflammation and/or prostanoid signaling in activity-dependent plasticity, pain feelings are temporarily decreased.