Paracetamol Impurities

The central analgesic action of paracetamol is mediated by the stimulation of descending serotonergic pathways.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
N-Nitroso Paracetamol Paracetamol

N-Nitroso Paracetamol

VE0010930 146897-60-1
Paracetamol CRS (P0300000) Paracetamol

Paracetamol CRS (P0300000)

PVE00278 103-90-2
Paracetamol EP Impurity A Paracetamol, Acetaminophen

Paracetamol EP Impurity A

VL2170006 614-80-2
Paracetamol EP Impurity B Paracetamol, Acetaminophen

Paracetamol EP Impurity B

VL2170005 1693-37-4
Paracetamol EP Impurity C Paracetamol

Paracetamol EP Impurity C

VL2170011 3964-54-3
Paracetamol EP Impurity D Paracetamol, Acetaminophen

Paracetamol EP Impurity D

VL2170007 103-84-4
Paracetamol EP Impurity E Paracetamol

Paracetamol EP Impurity E

VL2170008 99-93-4
Paracetamol EP Impurity F Paracetamol / Acetaminophen

Paracetamol EP Impurity F

VL2170003 100-02-7
Paracetamol EP Impurity G Paracetamol

Paracetamol EP Impurity G

VL2170004 34523-34-7
Paracetamol EP Impurity H Paracetamol

Paracetamol EP Impurity H

VL2170009 2623-33-8
Paracetamol EP Impurity I Paracetamol

Paracetamol EP Impurity I

VL2170010 118-93-4
Paracetamol EP Impurity J Paracetamol

Paracetamol EP Impurity J

VL2170002 539-03-7
Paracetamol EP Impurity K Paracetamol

Paracetamol EP Impurity K

VL2170001 123-30-8
Paracetamol EP Impurity M Paracetamol

Paracetamol EP Impurity M

VE006484 1752-24-5
Paracetamol EP Impurity O Paracetamol

Paracetamol EP Impurity O

VE0010403 2575516-61-7
Paracetamol Impurity J CRS (Y0001945) Paracetamol

Paracetamol Impurity J CRS (Y0001945)

PVE00240 539-03-7
Budesonide for System Suitability CRS (Y0001148) Paracetamol

Paracetamol Impurity K CRS (Y0001955)

PVE00345 123-30-8

Paracetamol Related Compound

There is some disagreement regarding its principal mode of action, which might be the suppression of prostaglandin (PG) production.

References

  • “What Is Paracetamol? | Information, Drug Uses | Fagron.” Fagron, 2023, fagron.com/compounding-matters/formula-groups/acetaminophen-paracetamol/#:~:text=Paracetamol%20belongs%20to%20the%20classes,reliever%20and%20fever%20reducer%2C%20respectively. Accessed 23 Mar. 2023.
  • Graham, Garry G., and Kieran F. Scott. “Mechanism of Action of Paracetamol.” American Journal of Therapeutics, vol. 12, no. 1, Jan. 2005, pp. 46–55, https://doi.org/10.1097/00045391-200501000-00008. Accessed 23 Mar. 2023.

FAQ

What drug class does paracetamol belong to?

Paracetamol is an analgesic and antipyretic medication that is extensively used as a pain reliever and fever reducer.

Is paracetamol a COX inhibitor?

In broken cell systems, paracetamol is a poor inhibitor of PG production of COX-1 and COX-2; however, therapeutic dosages of paracetamol block PG synthesis in intact cells in vitro when the levels of the substrate arachidonic acid are low (less than roughly 5 mumol/L).