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Penciclovir Impurities

Penciclovir is an antiviral medication primarily used for the topical treatment of herpes labialis (cold sores) caused by the herpes simplex virus (HSV-1). It is a guanine analogue and belongs to the class of nucleoside analog antiviral agents.
Penciclovir works by inhibiting viral DNA polymerase, which interferes with the replication of viral DNA. This action helps to shorten the duration of cold sore symptoms and accelerate healing. It is most effective when applied at the earliest signs of a cold sore outbreak.
Penciclovir is typically marketed as a topical cream (1%) and is available under the brand name Denavir, among others.

Structure

Product Name

CAS No.

Cat No.

Action

N-Nitroso Penciclovir Impurity 1

N-Nitroso Penciclovir Impurity 1

Parent: Penciclovir

CAS No.: N/A

Cat No.: VE0024513

Penciclovir 4-Dehydroxy 4-Chloro Impurity

Parent: Penciclovir

CAS No.: 100199-40-4

Cat No.: VE008922

Penciclovir Diacetate

Parent: Penciclovir

CAS No.: 97845-72-2

Cat No.: VE008931

Penciclovir Monoacetate

Parent: Penciclovir

CAS No.: 97845-80-2

Cat No.: VE008929

2-Deamino-(2,3-Dihydro-2-Oxo) Penciclovir

Parent: Penciclovir

CAS No.: 108970-74-7

Cat No.: VE0018765

7-(2-bromoethyl)-6-chloro-7H-purin-2-amine

Parent: Penciclovir

CAS No.: N/A

Cat No.: VE0021179

Penciclovir Related Compound

Impurities in penciclovir can arise from chemical synthesis, storage, or formulation processes and are controlled to ensure drug quality, stability, and safety in compliance with ICH and pharmacopeial guidelines.

Types of Impurities in Penciclovir

Process-Related Impurities

Unreacted precursors from guanine derivative synthesis
Side products from hydroxymethylation or glycosylation steps
Residual solvents such as dimethylformamide (DMF) or ethanol

Degradation Impurities

Hydrolyzed derivatives under humid conditions
Oxidative degradation when exposed to air or light
Thermal degradation products from improper storage

Elemental Impurities

Trace metals (e.g., iron, palladium, or copper) from catalysts or production equipment

Analytical Techniques for Impurity Detection

High-Performance Liquid Chromatography (HPLC)
Gas Chromatography (GC)
Mass Spectrometry (MS)
Nuclear Magnetic Resonance (NMR)
Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for elemental impurities

FAQ