Sulfadimidine or sulfamethazine is a sulfonamide antibacterial. There are non-standardized abbreviations for it as "sulfadimidine" and as "sulfamethazine". Other names include sulfadimerazine, sulfadimezine, and sulphadimethylpyrimidine. Chemically it is a para-aminobenzenesulfonamide with formula C12H14N4O2S and a molecular weight of approximately 278.3 g mol-1 (CAS 57-68-1). In its commercial form it appears as a white to pale yellow crystalline powder, sparingly soluble in water and more soluble in alkaline media due to ionization; it is soluble in common organic solvents such as ethanol and dimethylformamide. The mode of action is bacteriostatic through competitive inhibition of dihydropteroate synthase, blocking folate biosynthesis in susceptible bacteria. Relevant technical properties for formulation and analytical control include a melting point typically reported near 275 to 280 degrees C, characteristic UV absorption for HPLC assays, and pKa behavior that permits enhanced solubility at elevated pH. Typical use contexts are veterinary and, historically, human antimicrobial therapy where monitoring of dose, residue limits and susceptibility is required.
Parent: Sulfadimidine / Sulfamethazine
Parent: Sulfadiazine / Sulfadimidine / Sulfamethazine / Sulfaguanidine
Parent: Sulfadimidine / Sulfadiazine
Parent: Sulfadimidine
Parent: Sulfamethoxazole /Sulfadiazine / Sulfadimidine / Sulfadimethoxine
Typical quality specifications for sulfadimidine raw material include an assay of not less than 98.0% on a dried basis and a related substances profile controlled by HPLC; total related compounds are commonly limited to not more than 2.0% with any individual unspecified impurity usually limited to 0.5% or less and known related impurities subject to specific tighter limits. Common related compounds and impurities encountered during synthesis and storage include N4-acetylsulfadimidine (acetylated metabolite), sulfadimerazine, sulfanilamide, desulfonated products, N-oxidation products and occasional dimeric or aniline-type byproducts. Typical auxiliary limits applied in quality control are loss on drying or water content control (for example <=0.5% by Karl Fischer depending on grade), heavy metals below pharmacopeial thresholds (commonly <20 ppm), and residual solvents controlled to ICH Q3C class limits when applicable.
Sulfadimidine is used as a sulfonamide antibacterial agent, historically in human medicine and commonly in veterinary medicine, to treat susceptible bacterial infections by inhibiting folate synthesis; specific indications and permitted uses vary by jurisdiction and species, and use requires adherence to residue and dosing guidelines.
Sulfadimidine belongs to the sulfonamide class of antimicrobial agents, acting as a competitive inhibitor of dihydropteroate synthase and producing bacteriostatic effects.
Another name for sulfadimidine is sulfamethazine; other synonyms include sulfadimerazine, sulfadimezine, and sulphadimethylpyrimidine.
Sulfamethazine is used as an antibacterial sulfonamide with indications similar to sulfadimidine, principally to treat infections by susceptible bacteria in veterinary practice and in some historical human uses; its application requires appropriate susceptibility testing, dosing, and compliance with regulatory residue limits.
