Tenofovir Impurities

Tenofovir is a medication used to treat human immunodeficiency virus infections (HIV).

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Diethyl (Hydroxymethyl) Phosphonate Tenofovir

Diethyl (Hydroxymethyl) Phosphonate

VE0020217 3084-40-0
Diethyl Phosphite Tenofovir

Diethyl Phosphite

VE0020091 762-04-9
Isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate Tenofovir

Isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate

VE0019830 379270-37-8
phenyl ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonochloridate Tenofovir

phenyl ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonochloridate

VE0019823 1392206-58-4
R-(-)-1,2-Propanediol Tenofovir

R-(-)-1,2-Propanediol

VE0020196 4254-14-2
Tenofovir (MOC-POC-PMPA) Tenofovir

Tenofovir (MOC-POC-PMPA)

VL470019 1246812-43-0
Tenofovir (R)-Propanol Impurity Tenofovir

Tenofovir (R)-Propanol Impurity

VE0019816 14047-28-0
Tenofovir (S)-Enantiomer Tenofovir

Tenofovir (S)-Enantiomer

VL470009 1432630-26-6
Tenofovir 9-Allyl Impurity Tenofovir

Tenofovir 9-Allyl Impurity

VE006716 4121-39-5
Tenofovir Adenine impurity / Adenosine EP Impurity A Tenofovir

Tenofovir Adenine impurity / Adenosine EP Impurity A

VL470025 73-24-5
Tenofovir Alafenamide Fumarate Tenofovir

Tenofovir Alafenamide Fumarate

VE009339 379270-38-9
Tenofovir Alafenamide Impurity Tenofovir

Tenofovir Alafenamide Impurity

VE0019819 2126010-05-5
Tenofovir bis (L-alanine isopropyl ester) Amide Tenofovir

Tenofovir bis (L-alanine isopropyl ester) Amide

VE0017761 1883563-86-7
Tenofovir Diethyl Ester (S)-Isomer Tenofovir

Tenofovir Diethyl Ester (S)-Isomer

VL470012 1217630-57-3
Tenofovir Dimer Tenofovir

Tenofovir Dimer

VE008551 1607007-18-0
Tenofovir Dimer (S)-Isomer Tenofovir

Tenofovir Dimer (S)-Isomer

VE0019826 N/A
Tenofovir Disoproxil Desmethyl Tenofovir

Tenofovir Disoproxil Desmethyl

VL470034 365417-53-4
Tenofovir Disoproxil Dimer Impurity Tenofovir

Tenofovir Disoproxil Dimer Impurity

VL470015 1093279-76-5
Tenofovir Disoproxil Fumarate Tenofovir

Tenofovir Disoproxil Fumarate

VE006981 202138-50-9
Tenofovir Disoproxil Fumarate Impurity (N6-CH2OH-POC PMPA) Tenofovir

Tenofovir Disoproxil Fumarate Impurity (N6-CH2OH-POC PMPA)

VE0014019 1244022-55-6
Tenofovir Disoproxil Fumarate IP Impurity A Tenofovir

Tenofovir Disoproxil Fumarate IP Impurity A

VL470024 211364-69-1
Tenofovir Disoproxil Fumarate IP Impurity D Tenofovir

Tenofovir Disoproxil Fumarate IP Impurity D

VL470022 1422284-15-8
Tenofovir Disoproxil Fumarate IP Impurity E Tenofovir

Tenofovir Disoproxil Fumarate IP Impurity E

VL470002 1244022-56-7
Tenofovir Disoproxil Fumarate IP Impurity G (Free Base) Tenofovir

Tenofovir Disoproxil Fumarate IP Impurity G (Free Base)

VE008089 1280130-08-6
Tenofovir Disoproxil Fumarate IP Impurity M Tenofovir

Tenofovir Disoproxil Fumarate IP Impurity M

VL470018 1422284-16-9
Tenofovir Disoproxil Isopropoxycarbonyl Impurity Tenofovir

Tenofovir Disoproxil Isopropoxycarbonyl Impurity

VE008090 1244022-54-5
Tenofovir Disoproxil Related Compound B Tenofovir

Tenofovir Disoproxil Related Compound B

VL470021 4121-40-8
Tenofovir Impurity 21 Tenofovir

Tenofovir Impurity 21

VE0018242 390409-48-0
Tenofovir Impurity 29 Tenofovir

Tenofovir Impurity 29

VE0017756 342631-41-8
Tenofovir IPR Impurity Tenofovir

Tenofovir IPR Impurity

VL470003 1246812-40-7
Tenofovir Isopropyl Impurity Tenofovir

Tenofovir Isopropyl Impurity

VL470031 1346597-36-1
Tenofovir ME Impurity Tenofovir

Tenofovir ME Impurity

VL470004 N/A
Tenofovir Methyl Ester Tenofovir

Tenofovir Methyl Ester

VE0018146 390409-27-5
Tenofovir Mixed Dimer Tenofovir

Tenofovir Mixed Dimer

VL470001 1093279-77-6
Tenofovir Mono POC Dimer Tenofovir

Tenofovir Mono POC Dimer

VL470014 1962114-92-6
Tenofovir Monoester Tenofovir

Tenofovir Monoester

VL470026 N/A
Tenofovir Monoethyl Ester Tenofovir

Tenofovir Monoethyl Ester

VL470011 1796545-19-1
Tenofovir Monoisoproxil Ethoxy Impurity Tenofovir

Tenofovir Monoisoproxil Ethoxy Impurity

VE008091 1796539-92-8
Tenofovir NPOC POC PMPA Tenofovir

Tenofovir NPOC POC PMPA

VL470008 1217542-13-6
Tenofovir Phenyl PMPA Tenofovir

Tenofovir Phenyl PMPA

VE008097 379270-35-6
Tenofovir Related Compound 10 Tenofovir

Tenofovir Related Compound 10

VE0017905 2053424-82-9
Tenofovir Related Compound 4 Tenofovir

Tenofovir Related Compound 4

VE008096 851456-00-3
Tenofovir Related Compound 9 Tenofovir

Tenofovir Related Compound 9

VE0018282 14047-27-9
(2S)-isopropyl 2-((((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate Tenofovir

(2S)-isopropyl 2-((((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate

VE0019829 N/A
(R)-1,2-Propylene Carbonate Tenofovir

(R)-1,2-Propylene Carbonate

VE0020136 16606-55-6
(R)-9-[2-(Diethylphosphonomethoxy)propyl] Adenine Tenofovir

(R)-9-[2-(Diethylphosphonomethoxy)propyl] Adenine

VE0010429 180587-75-1
(S)-phenyl hydrogen bis((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)diphosphonate Tenofovir

(S)-phenyl hydrogen bis((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)diphosphonate

VE0019827 N/A
6N-Hydroxymethyl Tenofovir Disoproxil Tenofovir

6N-Hydroxymethyl Tenofovir Disoproxil

VE0014020 1244022-53-4

Tenofovir Related Compound

The virus that causes acquired immunodeficiency syndrome is HIV (AIDS).

References

FAQ

What is the therapeutic effect of tenofovir?

Tenofovir-diphosphate inhibits HIV replication by competing for incorporation into DNA during HIV transcription with the natural substrate deoxyadenosine 5′-triphosphate. Tenofovir-diphosphate prevents HBV replication by blocking HBV polymerase.

Can tenofovir be used to treat hepatitis B?

Tenofovir disoproxil fumarate, tenofovir alafenamide, and adefovir are nucleotide reverse transcriptase inhibitors (NRTIs) used to treat chronic HBV infection. Tenofovir, on the other hand, has mostly replaced adefovir because it is more powerful.

Do NRTIs include tenofovir?

Tenofovir, an ester prodrug of the nucleotide reverse transcriptase inhibitor (NRTI) tenofovir, is used to treat HIV infection in combination with other antiretroviral drugs.