Impureza 2-Oxoarginina (AKA 2-Oxoarginine) | CAS 3715-10-04 | sinônimos: 5-carbamimidamido-2-oxopentanoic acid; 2-Oxo-5-guanidinovaleric acid; 5-[(diaminomethylidene)amino]-2-oxopentanoic acid | representa um degradante polar de aminoácidos guanidínicos que compromete pureza e estabilidade de matérias-primas. Caracteriza-se como ácido cetônico e guanidínico | solúvel em água e detectável por HPLC-UV | LC-MS e análises de aminoácidos após derivatização. Formação é favorecida por oxidação | variação de pH e armazenamento em presença de umidade. Controle analítico robusto | limites de especificação conforme ICH Q3B e estratégias de mitigação na síntese e purificação são essenciais para reduzir seu impacto no perfil de impurezas e garantir conformidade regulatória.
Referências
Silva, Siguara B. L., et al. “Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges.†Angewandte Chemie, vol. 131, no. 2, 6 Dec. 2018, pp. 530–535, 10.1002/ange.201809539. Accessed 27 Jan. 2022.
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