Bromfenac Acyl-β-D-Glucuronide é uma impureza relacionada ao bromfenac observada em estudos de estabilidade e biotransformação | cuja detecção é crítica para o perfil de impurezas de lotes farmacêuticos. Caracteriza-se por maior polaridade que o princípio ativo e é normalmente identificado por técnicas LC-MS/MS e HPLC-UV com confirmação por espectrometria de alta resolução e RMN. Sua monitorização permite avaliar vias de conjugação e possíveis produtos de degradação | orientar limites e critérios de aceitação e suportar estratégias de controle de processo. Estudos toxicológicos e de degradabilidade suportam a definição de especificações analíticas robustas para este composto.
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![1H,1'H-[5,5'-biindole]-7,7'-diylbis((4-bromophenyl)methanone)](https://veeprho.com/wp-content/uploads/2023/05/1H-1-H-5-5-biindole-7-7-diylbis-4-bromophenyl-methanone.png "1H,1'H-[5,5'-biindole]-7,7'-diylbis((4-bromophenyl)methanone)")
