Citalopram Didesmethyl Impurity (Free base), também denominada N,N-DiDesmethyl Citalopram, CAS 62498-69-5, é uma impureza de processo relevante em perfis analíticos de citalopram. A molécula apresenta perda de grupos metila no anel amina terciária e requer monitoramento por HPLC-MS e RMN para quantificação e caracterização estrutural. Sua presença, mesmo em baixos níveis, influencia especificações de pureza, estabilidade e investigação de vias sintéticas, exigindo limites de aceitação e métodos validados para detecção. Dados de solubilidade em solventes orgânicos, comportamento térmico e padrões de retenção são essenciais para controle de qualidade e estudos de degradação.
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