A Impureza G do Citalopram (Citalopram EP Impurity G | CAS 1329745-98-3 | também referida como EsCitalopram EP Impurity G) é um subproduto identificado durante síntese e estudos de estabilidade do princípio ativo. Seu perfil químico é caracterizado por cromatografia líquida de alta eficiência HPLC com detecção UV e confirmação por LC-MS e RMN. A monitorização desta impureza segue requisitos do European Pharmacopoeia e das diretrizes ICH Q3A/Q3B | com limites de aceitação estabelecidos em controles de qualidade e estudos de estabilidade. A identificação precoce e quantificação rigorosa são essenciais para garantir conformidade de matéria prima farmacêutica e segurança do processo.
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