A L-tirosina, também designada Levodopa EP Impurity B e Phenylalanine EP Impurity C, é o aminoácido aromático 4-hidroxi-L-fenilalanina (CAS 60-18-4), com fórmula molecular C9H11NO3 e massa molecular de 181.07 g/mol. Estruturalmente, corresponde a um derivado da fenilalanina hidroxilado em posição para e está intimamente ligada, por vias biossintéticas e catabólicas, aos precursores das catecolaminas. Em contexto farmacopeico, pode surgir como impureza relacionada ao processo ou como resultado de conversão incompleta, hidrólise ou oxidação em rotas de fabricação de levodopa e fenilalanina. A identificação e quantificação normalmente exigem LC-MS/MS, LC-UV e, para níveis traço, HRMS ou LC quiral.
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