O di-hidrocloreto de (R)-3-aminopiperidina, CAS 334618-23-4, é o sal hidrocloreto de um heterociclo saturado quiral com amina primária na posição 3. Com fórmula molecular C5H14Cl2N2 e massa molar de 173.08 g/mol, é frequentemente observado como impureza relacionada ao processo ou intermediário sintético na química de piperidinas, decorrente de resolução estereoquímica incompleta ou de rotas secundárias durante aminação redutiva e formação do anel. Por ser uma amina básica e polar, sua caracterização normalmente exige LC-MS/MS, HILIC-LC e separações quirais, com GC-MS após derivatização quando se requer perfil volátil. A avaliação regulatória concentra-se na origem da impureza e na integridade enantiomérica.
Referências
Petri, Antonella, et al. “Asymmetric Synthesis of a High Added Value Chiral Amine Using Immobilized o-Transaminases.” Beilstein Journal of Organic Chemistry, vol. 15, Jan. 2019, pp. 60–66, https://doi.org/10.3762/bjoc.15.6.
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