(3S,4S)-Tofacitinib, CAS 1092578-47-6, é uma impureza estereoisomérica relacionada ao inibidor de JAK tofacitinib e deve ser interpretada como impureza de processo ou estereoquímica, e não como farmacóforo distinto. Com fórmula molecular C16H20N6O e massa molecular de 312.37 g/mol, difere do composto alvo apenas pela configuração absoluta nas posições 3 e 4 do esqueleto derivado de piperidina. Espécies epiméricas ou diastereoméricas desse tipo podem surgir por deriva na síntese assimétrica, atribuição incorreta de blocos quirais ou racemização em etapas tardias. A quantificação normalmente requer LC-MS/MS quiral ou LC-UV enantiosseletivo, com confirmação ortogonal por RMN quando a atribuição estrutural é necessária.
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