Albuterol Related Compound E, auch bezeichnet als Salbutamol EP Impurity F, Salbutamol BP Impurity F oder Salbutamol Dimer Ether, ist eine dimerische Ether-Verunreinigung des phenylethanolaminischen Bronchodilatators Salbutamol. CAS 147663-30-7 beschreibt die freie Base mit der Summenformel C26H40N2O5 und einer Molmasse von 460,61 g/mol. Die Struktur weist auf eine oxidative oder prozessbedingte Etherifizierung zwischen salbutamolabgeleiteten phenolischen Funktionen hin und nicht auf eine primäre Degradantenklasse wie Nitrosamine. Wegen der engen physikochemischen Ähnlichkeit zum Wirkstoff erfordert die Trennung meist RP-LC mit UV-Detektion und LC-MS/MS-Bestätigung; bei Spurenanalytik wird häufig hochauflösende Massenspektrometrie eingesetzt.
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