Bilastin-N-oxid (CAS 2069238-47-5) ist das tertiäre Amin-N-oxidationsprodukt von Bilastin und stellt eine polare oxidative Verunreinigung dar, die typischerweise während der Herstellung oder Lagerung unter peroxide- oder sauerstoffreichen Bedingungen entsteht. Mit der Summenformel C28H37N3O4 und einer Molekülmasse von 479,61 g/mol behält es das Grundgerüst des Wirkstoffs bei, weist jedoch eine erhöhte Heteroatom-Oxygenierung und chromatographische Polarität auf. Die Strukturzuordnung erfordert in der Regel LC-MS/MS mit hochauflösender Massenbestätigung, häufig ergänzt durch HILIC oder ionenpaarbasierte RP-HPLC, und kann durch NMR abgesichert werden. Obwohl kein Nitrosamin, ist es für das Verunreinigungsprofil und die Oxidationsbewertung relevant.
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