Eltrombopag Impurity 10, auch als Eltrombopag Amino Impurity bezeichnet, entspricht der CAS-Nummer 376592-93-7 und ist strukturell als 3-(3-amino-2-hydroxyphenyl)benzoesäure definiert, eine anilinische phenolische Carbonsäure mit Bezug zum Eltrombopag-Gerüst. Mit der Summenformel C13H11NO3 und einer Molmasse von 229,24 g/mol handelt es sich wahrscheinlich um einen prozessbedingten Begleitstoff oder ein Zwischenprodukt aus unvollständiger Arylkuppelung beziehungsweise Aminierung. Die aromatische Amino- und Phenolfunktion kann die chromatographische Trennung erschweren und oxidative Folgereaktionen begünstigen. Die Spurenbestimmung erfordert typischerweise LC-MS/MS, LC-HRMS und bei Bedarf NMR-gestützte Strukturaufklärung; reine UV-Detektion reicht für eine sichere Zuordnung meist nicht aus.
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![2-aminoethyl (E)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate](https://veeprho.com/wp-content/uploads/2025/11/2-aminoethyl-E-3-2-1-34-dimethylphenyl-3-methyl-5-oxo-15-dihydro-4H-pyrazol-4-ylidenehydrazineyl-2-hydroxy-11-biphenyl-3-carboxylate-NA-VE0025853.png "2-aminoethyl (E)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazineyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate")
