5-Oxo Atorvastatin, CAS 1391052-82-6, ist eine oxidative Verunreinigung des Statin-Gerüsts, gekennzeichnet durch die Ketobildung an der 5-Position der pyrrolbasierten Heptansäure-Seitenkette. Die Summenformel C33H33FN2O5 entspricht einer Molekülmasse von 556,62 g/mol und beschreibt ein monooxygeniertes Atorvastatin-Derivat. Die Bildung ist typischerweise mit oxidativem Abbau während Synthese, Lagerung oder Stressbelastung verbunden und nicht mit einem gezielt hergestellten Zwischenprodukt. Strukturaufklärung und Bestimmung im Spurenbereich erfordern üblicherweise LC-MS/MS, HRMS und stabilitätsindizierende HPLC-Verfahren, ergänzt durch NMR zur eindeutigen Zuordnung. Die Substanz ist für das Verunreinigungsprofil gemäß pharmakopöischen und ICH Q3A/Q3B-Rahmenwerken relevant.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
