Atorvastatin Related Compound E, auch als Atorvastatin EP Impurity E, Ent-Atorvastatin und Calciumsalz des Atorvastatin-3S,5S-Isomers bezeichnet, ist das enantiomere Stereoisomer von Atorvastatin und kein klassisches Abbauprodukt oder genotoxisches Strukturwarnmotiv. CAS 1105067-88-6; Summenformel C66H68CaF2N4O10; Molekulargewicht 1155.34 g/mol. Das Auftreten weist typischerweise auf stereochemische Inversion oder Verunreinigung aus der asymmetrischen Synthese hin und muss vom pharmakologisch aktiven 3R,5R-Konfigurationsisomer abgegrenzt werden. Für die Spurenanalytik sind chiral LC, LC-MS/MS und hochauflösende Massenspektrometrie erforderlich, um Isomere und salzassoziierte Spezies sicher zu unterscheiden. Regulatorisch steht die stereochemische Reinheit im Mittelpunkt.
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