5-Oxo Atorvastatin, CAS 1391052-82-6, es una impureza oxidativa del esqueleto de estatina, caracterizada por la formación de una cetona en la posición 5 de la cadena lateral heptanoica basada en pirrol. Su fórmula molecular, C33H33FN2O5, corresponde a un peso molecular de 556,62 g/mol, coherente con un derivado monooxigenado de atorvastatina. Su formación se asocia habitualmente con degradación oxidativa durante la síntesis, el almacenamiento o la exposición a estrés, más que con un intermediario deliberado. La elucidación estructural y la cuantificación a nivel traza requieren por lo general LC-MS/MS, HRMS y métodos HPLC indicativos de estabilidad, con RMN para la asignación definitiva. Es relevante en perfiles de impurezas bajo marcos farmacopéicos e ICH Q3A/Q3B.
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