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2517964-85-9Abiraterone Acetate N-Oxide

● Under Development

Katalog-Nr.::	VL830049
CAS-Nr.::	2517964-85-9
Summenformel::	C26H33NO3
Molare Masse::	407.55 g/mol

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Zusätzliche Informationen zu CAS 2517964-85-9

Parent drug

Abiraterone

IUPAC-Name

3-((3S, 8R, 9S, 10R, 13S, 14S)-3-acetoxy-10, 13-dimethyl-2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 14, 15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine 1-oxide

Pharmakopöe-Synonyme

N/A

Other Synonyms

17-(Pyridin-3-yl)androsta-5,16-dien-3Î²-yl Acetate N-oxide

SMILES

C[C@@]12C(C3=C[N+]([O-])=CC=C3)=CC[C@@]1([H])[C@]4([H])CC=C5C[C@@H](OC(C)=O)CC[C@]5(C)[C@@]4([H])CC2

InChI

InChI=1S/C26H33NO3/c1-17(28)30-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27(29)16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1

Beschreibung

Abiraterone Acetate N-Oxide is an impurity of Abiraterone acetate that is a prodrug used in castration-resistant prostate cancer by getting converted in vivo to abiraterone that acts by an androgen biosynthesis inhibition. It affects cancerous tissue as well as the natural synthesis of androgens.

References

Mach, Samuel, et al. â€œEpoxidation Is the Preferred Pathway of First-Stage Metabolism of Abiraterone Acetate in Brown Bullhead (Ameiurus Nebulosus).â€ Environmental Science and Pollution Research, vol. 26, no. 34, Oct. 2019, pp. 34896â€“904, https://doi.org/10.1007/s11356-019-06568-y. ?