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포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

2517964-85-9Abiraterone Acetate N-Oxide

● Under Development

카탈로그 번호:	VL830049
CAS 번호:	2517964-85-9
분자식:	C26H33NO3
분자량:	407.55 g/mol

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모약물

Abiraterone

IUPAC명

3-((3S, 8R, 9S, 10R, 13S, 14S)-3-acetoxy-10, 13-dimethyl-2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 14, 15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine 1-oxide

약전 동의어

N/A

Other Synonyms

17-(Pyridin-3-yl)androsta-5,16-dien-3Î²-yl Acetate N-oxide

SMILES

C[C@@]12C(C3=C[N+]([O-])=CC=C3)=CC[C@@]1([H])[C@]4([H])CC=C5C[C@@H](OC(C)=O)CC[C@]5(C)[C@@]4([H])CC2

InChI

InChI=1S/C26H33NO3/c1-17(28)30-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27(29)16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1

설명

Abiraterone Acetate N-Oxide is an impurity of Abiraterone acetate that is a prodrug used in castration-resistant prostate cancer by getting converted in vivo to abiraterone that acts by an androgen biosynthesis inhibition. It affects cancerous tissue as well as the natural synthesis of androgens.

References

Mach, Samuel, et al. â€œEpoxidation Is the Preferred Pathway of First-Stage Metabolism of Abiraterone Acetate in Brown Bullhead (Ameiurus Nebulosus).â€ Environmental Science and Pollution Research, vol. 26, no. 34, Oct. 2019, pp. 34896â€“904, https://doi.org/10.1007/s11356-019-06568-y. ?