ADK-2 (Atorvastatin)-Verunreinigung, CAS 88675-31-4, ist eine bromofluorierte aromatische Carbonylverbindung mit der Summenformel C14H10BrFO und einer Molekülmasse von 293,13 g/mol. Strukturell handelt es sich um ein halogeniertes Synthese-Nebenprodukt und nicht um einen pharmakopöischen Abbauartikel; sein Auftreten ist mit unvollständiger Kontrolle elektrophiler aromatischer Substitutionen oder der Seitenkettenassemblierung bei der Herstellung von Statinzwischenstufen vereinbar. Aufgrund des Bromatoms erfolgt die Bestätigung typischerweise mittels LC-MS/MS unter Auswertung des Isotopenmusters, ergänzt durch HPLC-UV und gegebenenfalls GC-MS nach Derivatisierung. Die Substanz ist für Impuritätsprofilierung und ICH-konforme Bewertung prozessbezogener Verunreinigungen relevant.
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