Albuterol Related Compound F, auch als Salbutamol-Ethylether-Hydrochlorid bezeichnet, ist eine prozessbedingte Verunreinigung mit Bezug zu β2-adrenergen Agonisten und besitzt die Summenformel C15H26ClNO3 bei einer molaren Masse von 303,82 g/mol. Die Verbindung entspricht der O-Ethylierung der phenolischen Hydroxylgruppe des Salbutamol-Gerüsts und ist damit als aus der Synthese stammendes Alkylether-Nebenprodukt oder als unbeabsichtigte Alkylierungsverunreinigung einzuordnen. Wegen der Salzform und ihrer analytischen Eigenschaften erfordert die Spurenbestimmung typischerweise LC-MS/MS oder hochauflösende LC-MS, ergänzt durch LC-UV oder NMR zur strukturellen Bestätigung im Impurity-Profiling. Die Bedeutung liegt vor allem in der regulatorischen Charakterisierung innerhalb von Verunreinigungsgrenzen für β2-Agonisten.
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