Amikacin EP Impurity A (CAS 50725-24-1) ist eine definierte aminoglykosidbezogene Prozessverunreinigung des halbsynthetischen Neomycin-Derivats Amikacin. Mit der Summenformel C22H43N5O13 und einer Molekülmasse von 585,60 g/mol entspricht sie strukturell einer eng verwandten glykosidischen Spezies, die durch unvollständige Acylierung, Seitenkettenübertragung oder andere synthetische Abweichungen während der Herstellung entstehen kann. Die stark polare, polykationische Natur begrenzt die Retention in der Reversed-Phase-Chromatographie und erfordert meist Ion-Pair- oder HILIC-Methoden in Kopplung mit MS oder Tandem-MS für eine empfindliche Charakterisierung. Da Spuren von Aminoglykosidverunreinigungen die toxikologische Bewertung beeinflussen können, wird diese Verbindung im Rahmen pharmakopöischer und ICH-orientierter Kontrollkonzepte erfasst.
References
Ristuccia AM, Cunha BA. An overview of amikacin. Therapeutic Drug Monitoring. 1985 ;7(1):12-25. DOI: 10.1097/00007691-198503000-00003. PMID: 3887667.http://europepmc.org/article/med/3887667 Wang, Jian, et al. “Separation and Characterization of Unknown Impurities in Amikacin Sulfate by HPLC–MS N.†ResearchGate, Springer Nature, 30 Aug. 2015, www.researchgate.net/publication/277921697_Separation_and_Characterization_of_Unknown_Impurities_in_Amikacin_Sulfate_by_HPLC-MS_n. Accessed 27 Oct. 2023.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
