Cabozantinib Carboxylic Acid, CAS 849217-77-2, ist eine definierte oxidative und hydrolytische Verunreinigung von Cabozantinib, die durch Oxidation der Seitenkette oder Spaltung der Amidbindung während Synthese, Lagerung oder Stressbedingungen entstehen kann. Mit der Summenformel C22H20N2O6 und einem Molekulargewicht von 408,4 g/mol handelt es sich um einen nicht flüchtigen, polaren Abbauwirkstoff und nicht um ein Nitrosamin oder eine andere direkte genotoxische Strukturwarnung. Der Nachweis erfolgt üblicherweise mittels LC-MS/MS, hochauflösender LC-MS sowie stabilitätsindizierender HPLC mit UV- oder Diodenarray-Detektion, ergänzt durch NMR zur Strukturbestätigung. In der Verunreinigungsanalytik dient es als Marker für molekularen Abbau und Prozessrobustheit.
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