Cabozantinib Carboxylic Acid, CAS 849217-77-2는 cabozantinib과 연관된 산화성 및 가수분해성 불순물로, 합성, 저장 또는 스트레스 조건에서 측쇄 산화나 아마이드 결합 절단을 통해 생성될 수 있다. 분자식 C22H20N2O6, 분자량 408.4 g/mol의 비휘발성 극성 분해산으로서, 니트로사민이나 기타 직접적인 유전독성 구조 경보에 해당하지 않는다. 검출 및 정량에는 LC-MS/MS, 고분해능 LC-MS, UV 또는 포토다이오드 어레이 검출을 갖춘 안정성 지시형 HPLC가 일반적으로 요구되며, 구조 확인에는 NMR이 보조적으로 사용된다. 불순물 프로파일링에서 이는 분자 분해와 공정 견고성의 지표로 작용한다.
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