849217-77-2Cabozantinib Carboxylic Acid

● In Stock

Catalogue No.:	VE007674
CAS No.:	849217-77-2
Mol. Formula:	C22H20N2O6
Mol. Weight:	408.4 g/mol

Request a quote

Add to RFQ list

Additional information on CAS 849217-77-2

Parent drug

Cabozantinib

IUPAC Name

1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid

Synonyms

N/A

Description

Cabozantinib Carboxylic Acid, CAS 849217-77-2, is a defined oxidative and hydrolytic impurity associated with cabozantinib, arising through side-chain oxidation or amide bond cleavage during synthesis, storage, or stress conditions. With molecular formula C22H20N2O6 and molecular weight 408.4 g/mol, it represents a non-volatile, polar degradant rather than a nitrosamine or other direct genotoxic structural alert. Its occurrence is typically investigated by LC-MS/MS, high-resolution LC-MS, and stability-indicating HPLC with UV or photodiode array detection, often supported by NMR for structural confirmation. In impurity profiling, it serves as a marker of molecular degradation and process robustness.