Cetirizin-4-Chlorbenzhydrol-Verunreinigung, auch als Meclizin Related Compound A und Meclozin EP Impurity B bezeichnet, ist ein chloriertes Diarylmethanol mit der CAS-Nummer 119-56-2, der Summenformel C13H11ClO und einer Molekülmasse von 218,68 g/mol. Strukturell handelt es sich um 4-Chlorbenzhydrol, einen aromatischen sekundären Alkohol, der als synthetisches Zwischenprodukt, prozessbedingte Restverunreinigung oder hydrolytisches Umwandlungsprodukt in Herstellungswegen verwandter Antihistaminika auftreten kann. Wegen geringer Polarität und aromatischer Struktur erfolgt die Spurenbestimmung typischerweise mittels LC-MS/MS, GC-MS oder HPLC mit UV-Detektion, häufig nach Derivatisierung für die gaschromatographische Analyse. Seine Erfassung ist für das Verunreinigungsprofil und die Spezifikationsfestlegung unter aktuellen regulatorischen Rahmenbedingungen relevant.
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