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13485-59-1Enalapril Alanyl Proline Impurity

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Katalog-Nr.::	VL1360014
CAS-Nr.::	13485-59-1
Summenformel::	C8H14N2O3
Molare Masse::	186.21 g/mol

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Zusätzliche Informationen zu CAS 13485-59-1

Parent drug

Enalapril

IUPAC-Name

L-Alanyl-L-proline

Pharmacopeial Synonyms

N/A

Synonyme

Enalapril Dipeptide Impurity; Enalapril Alanyl Proline Impurity; (S)-1-((S)-2-Aminopropanoyl)pyrrolidine-2-carboxylic acid; 1-L-Alanyl-L-proline

SMILES

O=C(O)[C@H]1N(C([C@H](C)N)=O)CCC1

InChI

InChI=1S/C8H14N2O3/c1-5(9)7(11)10-4-2-3-6(10)8(12)13/h5-6H,2-4,9H2,1H3,(H,12,13)/t5-,6-/m0/s1

Shipping Condition

Ambient Temperature

Beschreibung

Enalapril Alanyl Proline Impurity (CAS 13485-59-1), also listed as Enalapril Dipeptide Impurity and 1-L-Alanyl-L-proline, is a synthetic dipeptide byproduct observed during enalapril synthesis and peptide coupling operations. The impurity corresponds to (S)-1-((S)-2-aminopropanoyl)pyrrolidine-2-carboxylic acid and demands focused analytical control using HPLC, LC-MS and amino acid analysis for unambiguous identification and accurate quantitation. Routine monitoring supports impurity profiling, specification setting and process optimization to reduce formation. Retention characteristics, physicochemical parameters and mass fragmentation data provide robust criteria for separation, structural confirmation and regulatory-compliant reporting in quality dossiers.