Ibuprofen EP Impurity D, CAS 938-94-3, bezeichnet 2-(4-Methylphenyl)propansäure, ein Stellungsisomer von Ibuprofen mit der Summenformel C10H12O2 und einer Molekülmasse von 164,2 g/mol. Diese Arylpropionsäure-Verunreinigung kann aus der Bildung des Isomers während der Synthese oder aus unzureichend gesteuerter Regioselektivität bei Alkylierungsschritten der Herstellung resultieren. Es handelt sich nicht um eine Nitrosamin- oder mutagene Spezies, jedoch ist sie für das Verunreinigungsprofil und die pharmazeutische Spezifikationsprüfung von Bedeutung. Die sichere Identifizierung erfolgt üblicherweise mittels HPLC mit Diodenarray-Detektion, LC-MS/MS zur Massenbestätigung und gegebenenfalls GC-MS nach Derivatisierung.
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