Leflunomid Verwandte Verbindung C, auch als Leflunomid EP-Verunreinigung C und Leflunomid meta-Isomer bezeichnet, ist das Positionsisomer im Verunreinigungsprofil der Leflunomid-Synthese. Die CAS-Nummer 61643-23-0 kennzeichnet ein fluoriertes Pyridinamid-Derivat mit der Summenformel C12H9F3N2O2 und einer Molmasse von 270,21 g/mol. Sein Auftreten wird gewöhnlich auf isomere Mitnahme oder regioselektive Nebenproduktbildung beim Aufbau des Trifluormethyl-Pyridin-Gerüsts zurückgeführt. Aufgrund der strukturellen Nähe zum Wirkstoff erfordert die Spurenbestimmung in der Regel LC-MS/MS und, falls nötig, hochauflösende LC-MS mit chromatographischer Trennung gegenüber verwandten Isomeren.
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